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Cell & Cellular Life Sciences Journal Research Article 1 min read

The Mingled Allies-Combined Hepatocellular Carcinoma and Cholangiocarcinoma

Bajaj A*
* Corresponding author
ISSN: 2578-4811  10.23880/cclsj-16000198  Received: January 08, 2024  Published: January 23, 2024
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 7 references
 2 figures
 1 table
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Keywords
Neoplasm Hepatocellular Carcinoma Hepatic Cirrhosis Fibrotic Stroma Cholangiocarcinoma
Abstract

Combined hepatocellular carcinoma and cholangiocarcinoma is an exceptionally discerned, primary malignant neoplasm incriminating the hepatic parenchyma. Neoplasm categorically exhibits an amalgamation of dual hepatocellular and biliary differentiation within a singular neoplasm. Notwithstanding, collision tumours do not configure as combined lesions.

Figures

Figure 1: Combined hepatocellular carcinoma and cholangiocarcinoma composed of cuboidal cells impregnated with pale, pink cytoplasm, intermingled with glandular articulations layered with malignant epithelium and an encompassing fibrotic stroma [5].
Click to enlarge
Figure 1: Combined hepatocellular carcinoma and cholangiocarcinoma composed of cuboidal cells impregnated with pale, pink cytoplasm, intermingled with glandular articulations layered with malignant epithelium and an encompassing fibrotic stroma [5].
Figure 2: Combined hepatocellular and cholangiocarcinoma demonstrating cuboidal cells pervaded with abundant eosinophilic cytoplasm and commingled glandular structures layered with malignant epithelium and circumscribing fibrotic stroma [6].
Click to enlarge
Figure 2: Combined hepatocellular and cholangiocarcinoma demonstrating cuboidal cells pervaded with abundant eosinophilic cytoplasm and commingled glandular structures layered with malignant epithelium and circumscribing fibrotic stroma [6].

Tables

WHO classification 4th editionWHO classification 5th edition
combined hepatocellular carcinoma and cholangiocarcinoma-classical typecombined hepatocellular carcinoma and cholangiocarcinoma-classical type
combined hepatocellular carcinoma and cholangiocarcinoma with stem cell features-classical typeintermediate cell carcinoma
combined hepatocellular carcinoma and cholangiocarcinoma with stem cell features- intermediate typeclassified with cholangiocarcinoma
combined hepatocellular carcinoma and cholangiocarcinoma with stem cell features- cholangiocellular typeclassified with cholangiocarcinoma

Table 1: Contemporary World Health Organization (WHO) classification of combined hepatocellular carcinoma and cholangiocarcinoma

References

  1. Roßner F, Sinn BV, Horst D (2023) Pathology of Combined Hepatocellular Carcinoma-Cholangiocarcinoma: An Update. Cancers (Basel) 15(2): 494.
  2. Amory B, Goumard C, Laurent A, Langella S, Cherqui D, et al. (2023) AFC-ICC-2009, AFC-LLR-2018, and PRS-2019 Study Group. Combined hepatocellular- cholangiocarcinoma compared to hepatocellular carcinoma and intrahepatic cholangiocarcinoma: Different survival, similar recurrence: Report of a large study on repurposed databases with propensity score matching. Surgery 175(2): 413-423.
  3. Lv TR, Hu HJ, Ma WJ, Liu F, Jin YW, et al. (2023) Meta- analysis of prognostic factors for overall survival and disease-free survival among resected patients with combined hepatocellular carcinoma and cholangiocarcinoma. Eur J Surg Oncol 50(1): 107279.
  4. Kim J, Joo DJ, Hwang S, Lee JM, Ryu JH, et al. (2023) Liver transplantation for combined hepatocellular carcinoma and cholangiocarcinoma: A multicenter study. World J Gastrointest Surg 15(7): 1340-1353.
  5. Image 1 Courtesy: Pathology outlines.
  6. Image 2 Courtesy: Research gate.
  7. Penzkofer L, Gröger LK, Hoppe-Lotichius M, Baumgart J, Heinrich F, et al. (2023) Mixed Hepatocellular Cholangiocarcinoma: A Comparison of Survival between Mixed Tumors, Intrahepatic Cholangiocarcinoma and Hepatocellular Carcinoma from a Single Center. Cancers (Basel) 15(3): 639.
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@article{bajaj2024,
  title   = {The Mingled Allies-Combined Hepatocellular Carcinoma and
Cholangiocarcinoma},
  author  = {Bajaj A},
  journal = {Cell & Cellular Life Sciences Journal},
  year    = {2024},
  volume  = {9},
  number  = {1},
  doi     = {10.23880/cclsj-16000198}
}
Bajaj A (2024). The Mingled Allies-Combined Hepatocellular Carcinoma and
Cholangiocarcinoma. Cell & Cellular Life Sciences Journal, 9(1). https://doi.org/10.23880/cclsj-16000198
TY  - JOUR
TI  - The Mingled Allies-Combined Hepatocellular Carcinoma and
Cholangiocarcinoma
AU  - Bajaj A
JO  - Cell & Cellular Life Sciences Journal
PY  - 2024
VL  - 9
IS  - 1
DO  - 10.23880/cclsj-16000198
ER  -