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Clinical Pathology & Research Journal Research Article 6 min read

Precision Medicine in Dengue Management: Advancements and Challenges

Gupta R*
* Corresponding author
ISSN: 2642-6145  10.23880/cprj-16000182  Received: February 01, 2024  Published: February 12, 2024
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Keywords
Dengue Risk Assessment Treatment Diagnostics Vaccine
Abstract

Dengue, a globally impactful mosquito-borne viral infection, is explored in Dr. Richa Gupta and Mansi Bhandari’s review on precision medicine. With an annual toll of 390 million infections and 22,000 deaths, primarily affecting children, dengue places immense strain on healthcare systems. The absence of specific antiviral medication makes supportive care the prevailing treatment

Opinion

Dengue, a globally impactful mosquito-borne viral infection, is explored in Dr. Richa Gupta and Mansi Bhandari’s review on precision medicine. With an annual toll of 390 million infections and 22,000 deaths, primarily affecting children, dengue places immense strain on healthcare systems. The absence of specific antiviral medication makes supportive care the prevailing treatment [1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20].

Precision medicine emerges as a transformative approach, finding applications in diagnostics, risk assessment, treatment customization, and vaccine development for dengue. The primary vectors, Aedes mosquitoes, particularly Aedes aegypti, transmit the virus, leading to diverse clinical manifestations, from mild symptoms to severe conditions like dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) [21, 22, 23, 24, 25].

In the context of dengue treatment, precision medicine tailors regimens based on individual characteristics to optimize efficacy and minimize adverse effects. Genetic testing and biomarker analysis play a crucial role in diagnostics, enabling early detection, risk assessment, and targeted preventive actions in high-risk areas [26, 27]. The authors stress the integration of precision medicine in healthcare plans, considering individual genetic, environmental, and lifestyle factors [28, 29, 30].

Opinion

The paper also highlights precision medicine’s pivotal role in vaccine development, factoring in genetic variations and immune responses to enhance efficacy and reduce risks [31, 32, 33]. A visual representation of the Precision Medicine Workflow for dengue is presented, illustrating its integration in diagnostics, risk assessment, treatment optimization, and vaccine development [34].

The review delves into the clinical symptoms and epidemiology of dengue, noting its prevalence in tropical and subtropical regions influenced by climate, urbanization, and population mobility [35]. From mild flu-like manifestations to severe conditions, early detection of high-risk individuals is deemed crucial.

Synonymous with personalized medicine, precision medicine shows promise in managing infectious diseases by tailoring healthcare decisions to individual genetic, environmental, and lifestyle characteristics. Its role in enhancing diagnostic methods through genetic testing and biomarker analysis is emphasized, allowing early diagnosis, risk estimation, and identification of high-risk patients [36, 37, 38].

In the absence of specific antiviral medications, the primary therapeutic approach for dengue involves supportive care, with ongoing research exploring promising alternatives like immunomodulatory drugs, herbal remedies, and innovative approaches such as monoclonal antibodies, antiviral peptides, host-targeted therapies, and RNA interference.

Challenges such as the high cost of tailored medications and advanced diagnostics pose barriers to precision medicine’s feasibility, particularly in economically disadvantaged areas. The authors propose collaboration among stakeholders, cost-sharing programs, and investments in affordable diagnostics and treatments. Telemedicine and mobile health technology are suggested to overcome accessibility challenges in resource-limited environments.

The review concludes by outlining future research directions, emphasizing the discovery of accurate biomarkers for dengue severity and treatment response. International collaboration and advancements in nanotechnology and point-of-care devices are highlighted for their potential to increase the accessibility of personalized treatment in resource-limited settings.

• Contributions: The author gratefully acknowledges Dr Richa Gupta, the corresponding author, for her invaluable supervision in guiding the conceptualization, structure, and scholarly rigour of this review article.

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@article{gupta2024,
  title   = {Precision Medicine in Dengue Management: Advancements and Challenges},
  author  = {Gupta R},
  journal = {Clinical Pathology & Research Journal},
  year    = {2024},
  volume  = {8},
  number  = {1},
  doi     = {10.23880/cprj-16000182}
}
Gupta R (2024). Precision Medicine in Dengue Management: Advancements and Challenges. Clinical Pathology & Research Journal, 8(1). https://doi.org/10.23880/cprj-16000182
TY  - JOUR
TI  - Precision Medicine in Dengue Management: Advancements and Challenges
AU  - Gupta R
JO  - Clinical Pathology & Research Journal
PY  - 2024
VL  - 8
IS  - 1
DO  - 10.23880/cprj-16000182
ER  -