Preparation and Characterization of Sodium Alginate- Eudragit E100 Based Systems with Prospective Pharmaceutical Delivery to Application

Authors: Voycheva CH*

DOI: 10.23880/oajpr-16000254

Volume 5, Issue 4

Abstract

Regarding the preparation of a local drug delivery system, the possibility of incorporating an active substance in a matrix system was investigated to prolong the drug release. A complex between sodium alginate and a triple copolymer of dimethyl aminoethyl methacrylate was prepared in the presence of a cross-linking agent- malic acid. The formation of a polyelectrolyte complex was proven by turbidimetry, determining the specific viscosity of the diluted solutions of sodium alginate, EE 100, malic acid with IR spectroscopy.

Keywords: Sodium Alginate; Eudragit E 100; Interpolymer Complexes; Modified Release; Biocompatibility

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