ISSN: 2577-4328
Authors: Rupa G*
It is imperative to have safety and efficacy evaluation completed for a test compound before proceeding to translate for clinical trials. Preclinical pharmacology and toxicological studies play an essential role for providing particulars to design clinical studies to determine whether the test compound is as efficacious and safe in humans as it was observed in animal studies. Study performed in preclinical setting includes determination of safety, efficacy, tolerability and toxicity for the test compound. These studies help to propose a safe and efficacious startup dose for human studies. Furthermore, it won’t be wrong to state that without these preclinical pharmacological and toxicological studies it is not possible to strategize and design clinical trial in humans.
Keywords: Pharmacology; Toxicology; Preclinical; Drug discovery; Translational studies; Hits; Lead
