Variability of the Predicted Final Height in Idiopathic Short Stature Over Time

Authors: Arani KS, Ahadiat SAA*, Hosseinian Z, Najafi S, Aghamahdi F and Akbari H

DOI: 10.23880/aabsc-16000201

Volume 6, Issue 1

Abstract

Background: Predicting the final height in children with idiopathic short stature is essential for starting growth hormone therapy. This study was conducted to assess final height estimation variability over time. Materials and Methods: In this cross-sectional study, children with idiopathic short stature were examined. Bone age and final height were estimated through the Greulich-Pile and Bayley-Pinneau method. This process repeated in the later visits with at least six months, and the results were compared statistically. The patients were classified based on the changes in predicted final height (PFH). Results: A total of 81 patients (46 boys, 35 girls) with a mean age of 11.09 years were enrolled. The calculated PFH in the first visit was 160.15±8.79 cm, which has decreased to 159.33±9.38 cm. Based on the second evaluation, 43 patients had few changes in PFH (±3 cm), 23 patients experienced a decrease in PFH of more than 3 cm, and 15 patients experienced an increase in PFH of more than 3 cm. A change in Tanner stage, weight gain, height velocity, target height, and the interval between the two evaluations were similar in all groups. Young under ten years had more decreasing in the PFH. Conclusion: Depending on bone age velocity, predicting the final height can change over time. As bone age velocity increases, PFH decreases more. PFH is also less reliable at younger ages and requires monitoring of growth and puberty and repeating final estimations later in life.

Keywords: Idiopathic short stature; Final height; Bone age; PFH

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