ISSN: 2474-9230
Authors: Kochar Kaur K*, Allahbadia G and Singh M
Earlier we had reviewed the role of sirtuins regarding SIRTs in the form of epigenetic modifiers regarding postponement of Diabetic Kidney Disease (DKD) apart from in placental growth in pregnancy besides how resveratrol could be used in numerous chronic inflammatory diseases and Autoimmune Diseases to target SIRT1. Furthermore, we had reviewed the role of mitochondrial function in reproductive endocrinology as well as its significance in sustenance of oocyte quality. Recently lot of work has been conducted to improve the oocyte quality in women presenting with advanced age or those coming in with diminished ovarian reserve (DOR) with use of various anti-oxidant along with anti-inflammatory agents like melatonin, resveratrol. Thus we conducted a narrative review utilizing search engine PubMed, google scholar ;web of science; embase; Cochrane review library utilizing the MeSH terms like Sirtuins; maternal ageing; Oxidative stress (OS); organs ageing; oocytes quality; embryo quality; implantation; mitochondria function; Epigenetics; DNA methylation; Histone deacetylation; Histone crotonylation; melatonin; resveratrol; nicotinamide mononucleotide; nicotinamide riboside; from1990 to 2023 till date. We found a total of 300 articles out of which we selected 110 articles for this review. No meta-analysis was done. We observed Oxidative stress to be the mode implicated in mitigating oocyte quality. Escalated corroboration from animal model in addition to Clinical studies have validated that Sirtuins confer protection from OS aiding in improvement of oocyte quality through an anti-oxidant action .Thus escalating research has concluded that Sirtuins possess protective part to oocyte quality. Soon there might be a time with the rate at which this research in mounting women will not need to cryopreserve gametes only due to choosing professional carreers.
Keywords: Oocyte Quality; Sirtuins; Maternal Ageing; Ovarian Ageing; Oxidative Stress
