ISSN: 2574-7770
Authors: Povarova OV*, Gorodetskaya EA, Kulyak OJ, Demyanenko AN, Alimova IL, Kalenikova EI and Medvedev OS
Biochemical indices in obese children for early metabolic syndrome (MS) diagnostics were analyzed. Prospective study enrolled control (n=32, -1.0≤BMI SD score ≤+1.0) and obese (n=40, BMI SD score>+2.0) groups of children (12 yr mean age). Obese children demonstrated enhanced total cholesterol, triglycerides, LDL, ALT, fasting insulin, HOMA-IR and elevated atherogenic index (AI). In most obese children, cardiovascular (40%) and hepatic (85%) disturbances were observed. Association of obesity with hepatic pathology was reflected in all examinees by correlations between BMI and ALT (r=0.511, p=0.001) and between BMI and ALT/AST ratio (r=0.638, p=0.001). AI increased in parallel with ALT/AST ratio elevation (r=0.436, р=0.006). Value of ALT/AST ratio in obese children group with signs of MS was 1.0 (0.5-1.6), exceeding value in control group (0.6; 0.3-1.1). To clarify ALT/AST ratio reference values as a manifestation of MS in obese children, an analysis of data from a larger number of patients is required. Control group demonstrated correlations between plasma coenzyme Q10 and total cholesterol (r=0.474, p=0.009) as well as between coenzyme Q10 and ALT (r=0.412, p=0.023) attesting to adequate lipoprotein antioxidant function and normal action of liver. In obese children, these relationships were distorted indicating advisability to prevent MS with membrane-stabilizing and/or antioxidant agents.
Keywords: Obesity; Children; Metabolic Syndrome; Coenzyme Q10; Non-Alcoholic Fatty Liver Dis-Ease; Alanine Aminotransferase
