Genome-Wide-Associated-Genetic Variants Identification in Critical COVID-19

Authors: Cheepsattayakorn A*, Cheepsattayakorn R and Siriwanarangsun P

DOI: 10.23880/oajprs-16000156

Volume 7, Issue 1

Abstract

A recent study using genome-wide association study (GWAS), a monocyte transcriptome-wide association study (TWAS) models, and Mendelian randomization revealed association of the critical COPVID-19 with genes relatedhost factors required for viral replication and entry, -immunometabolism, monocyte-macrophage activation and endothelial permeability, and inflammatory signalling; RAB2A and TMPRSS2 (Figure 1) [1], AK5 and SLC2A, PDE4A, and JAK1, respectively [1]. There was critical correlations between predicted gene expression in monocyte [2], blood [3], and lung (Figure 2) [1, 4, 5].

Keywords: Genome Wide Association Study;Transcriptome Wide Association Study; Linkage Disequilibrium

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