ISSN: 2577-4379
Authors: Hassan BAR* and Mohammed AH
Alzheimer's disease (AD) is a major contributor to the worldwide prevalence of dementia. Extracellular-amyloid (A) senile plaques (SP) and intracellular neurofibrillary tangles (NFT) are the neuropathological hallmarks of Alzheimer's disease. Currently, it is believed that both hereditary and environmental variables interact to contribute to the pathophysiology of AD. Despite significant investments in neurological research, the precise molecular basis of AD pathogenesis remains unknown. Multiple studies point to the possibility that pathogenic microorganisms contribute to the development of AD. Microbes were formerly thought to have no connection to Alzheimer's disease, but a rising body of research suggests otherwise. Evidence that these microbes cause AD-specific cognitive and neuropathological deficits and changes is lacking, casting doubt on the hypothesis that AD is an infectious neurological illness. In addition, the gut flora may have a role in AD progression in humans.
Keywords: Microbial Infections; Gut Microbiota; Alzheimer's Disease; Pathophysiology
