Association of Tumor Necrosis Factor-α 308A/G Gene Polymorphism with Obesity among a Population of Southwestern Nigeria

Authors: Ayelagbe OG , Ayelagbe OG , Adedokun BG , Kolawole OT and Adewole TA

DOI: 10.23880/jcstm-16000118

Volume 5, Issue 1

Abstract

Obesity often results from interplay of genetics, nutrition and lifestyle. A polymorphic variant of the Tumor Necrosis Factor-α (TNF- α) promoter region (308G/A) is associated with increased production of TNF- α protein, which could lead to fat accumulation implicated in the development of obesity and cardiovascular disease. This study investigated the association of TNF-α 308G/A polymorphism with obesity among a population residing in Southwestern Nigeria. Two hundred (200) obese and 197 age and sex matched non-obese subjects were enrolled. Blood pressure, weight, height, waist and hip circumferences were measured. Estimation of fasting blood sugar level, DNA extraction from whole blood and genotyping of single nucleotide polymorphisms of TNF-α 308G/A were done using standard laboratory procedures. Data were analyzed and p-value < 0.05 was considered significant. Mean body weight and BMI were significantly increased in the obese group (81.92±1.00 kg, 33.01±0.25kg/m2) compared with controls (72.03±1.01 kg, 22.06±0.22kg/m2). Waist and hip circumferences were increased among obese subjects (p

Keywords: Nigerian; Obesity; Polymorphism; Tumor Necrosis Factor-α

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