ISSN: 2574-7800
Authors: Baybay H , Elloudi S , Soughi M , Douhi Z and Mernissi FZ
Overgrowth syndromes are characterized by Global or localized excessive growth coupled with additional abnormalities, such as vascular malformations and neurological and/or visceral disorders. Cloves syndrome is a recently described overgrowth syndrome caused by a mutation of an allele of the PIK3CA gene. It is an acronym for congenital lipomatous overgrowth, vascular malformations, epidermal nevi and skeletal anomalies, scoliosis and spinal anomalies. It is characterized by an asymmetrical body hypertrophy with macrodactyly and scoliosis, a distinctive thoraco-abdominal congenital lipomatous hamartoma, and various malformations, particularly vascular malformations including capillary, venous, lymphatic micro or macrocystic malformations, and rarely arteriovenous malformations, often located opposite the lipomatous masses.
Keywords: Overgrowth
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