ISSN: 2993-8260
Authors: Sabeen F*
Background and Objective: Pre-eclampsia and eclampsia are common complications in pregnancy, and they lead to utero placental vascular insufficiency. More than 38% of pregnant women succumb to seizures without meeting the clinical criteria for pre-eclampsia and eclampsia. This signifies the importance of a confirmatory diagnosis of pre-eclampsia or eclampsia using the histopathological changes seen in placenta . Hence, the aim of the study was to determine the incidence of histopathological abnormalities in the placentas of singleton pregnancies with hypertensive disorders. Materials & Methods: The study was carried out at Rajendra Institute of Medical Sciences, Ranchi, India from June 2018 to July 2020. In this study spanning two years, 134 cases of pre-eclampsia/eclampsia were included. Placenta tissues were collected from the labor room and histological slides were prepared in the Histology Lab. All the steps of Tissue Processing were done and slides were observed under the light microscope after proper staining. Results: A significant association between the histopathological parameters of the placenta, including fibrin deposition, syncytial knots, hypovascular villi and clinical diagnosis of pre-eclampsia and eclampsia was found. Conclusion: This study elucidates a significant association between placental histopathological patterns, caused by preeclampsia and eclampsia.
Keywords: Eclampsia; Pre-eclampsia; Stromal Fibrosis; Fibrinoid Necrosis; Hypovascular Villi; Syncytial Knots
