Synthesis of Hydrogels Containing Halloysite and Investigation of Antiproliferative Activity

Authors: Sökmen O, Çankaya N* and Azarkan Yalcin S

DOI: 10.23880/act-16000274

Volume 8, Issue 3

Abstract

In this study, superabsorbent hydrogels containing halloysite clay, biopolymer (CMC, carboxymethyl cellulose), acrylamide (AM) and 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS) were synthesized and characterized by free radical polymerization method. Then, the cytotoxic effect of hydrogels on MDA-MB-231 breast cancer cells was evaluated. According to the findings, hydrogels were successfully synthesized and their cytotoxic properties were supported by in vitro studies. In order for these hydrogels to be used as a drug delivery system, their potential properties need to be supported by further research such as in vivo.

Keywords: Acrylamide; 2-Acrylamido-2-Methyl-1-Propanesulfonic Acid; Halloysite; Hydrogel; MDA-MB-231 Breast Cancer Cell Line

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