Immunogenic Outer membrane Proteins (Omps) of Salmonella: Potential Candidate for sub-unit vaccine

Authors:

Yashpal Singh, Anjani Saxena, Rajesh Kumar, Prakash Bhatt and MK Saxena*

DOI: 10.23880/vij-16000109

Volume 1, Issue 2

Abstract

The outer membrane is a continuous structure on the surface of Gram-negative bacteria and has particular significance as one of the potential targets for protective immunity. Recent studies have focused attention on the outer membrane proteins (OMPs) suggesting the existence of protective immunogenic components in Salmonella. Outer membrane protein (OMPs) has been reported to be immunogens for eliciting active/protective immunity against Salmonella and thus, have great potential for use in vaccination. OMPs have been investigated as potential vaccine candidates, virulence factors and these surface exposed proteins play a critical role in pathogenic processes such as motility, adherence and colonisation of the host cells, injection of toxins and cellular proteases, as well as the formation of channels for the removal of antibiotics (antibiotic resistance).

Keywords:

Outer membrane protein; Immunogens; Salmonella

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