ISSN: 2576-4772
Authors: Yadav P, Gupta T* and Nayak A
Rheumatoid arthritis (RA) is indeed a severe autoimmune condition characterized by chronic inflammation of the joints. It is known to cause pain, stiffness, swelling and eventually, joint deformity. Phytochemicals, which are biologically active compounds found in plants, have shown promise in the management of arthritis and the treatment of inflammatory, autoimmune and infectious disorders. Thus, the phytochemicals derived from plants have been used to treat autoimmune diseases like RA, and their pharmacological effects have been recognized for a long time. However, despite a wealth of scientific data supporting their medicinal potential, phytochemicals are often overlooked in mainstream medicine. One approach to enhance the effectiveness of phytoconstituents is through the use of nanomedicine. Nanomedicine involves formulating drugs at the nanoscale to improve their bioavailability, stability, and biotransformation. By using nanotechnology, phytoconstituents can be encapsulated in solid nanoparticles, which can enhance their therapeutic effects. It has shown that drug-loaded solid nanoparticles are more effective in reducing arthritic signs and symptoms. The physicochemical characteristics of these nanoformulations, including their drug loading effectiveness, are important factors in determining their efficacy. Overall, the utilization of phytochemicals in the treatment of arthritis and other related disorders, along with the application of nanomedicine techniques, holds promise for improving patient outcomes and addressing the challenges associated with the bioavailability and stability of these compounds.
Keywords: Arthritis; Rheumatoid Arthritis; Phytochemicals; Nanoformulations
