Overcoming Malignant Glioma Therapeutic Challenges: Nanocarrier-Mediated Delivery of Immune Checkpoint Blockers via Nasal Route

Authors: Hassan HAFM*

DOI: 10.23880/nnoa-16000249

Volume 8, Issue 3

Abstract

Malignant glioma represents a prevailing malignancy within both paediatric and adult populations, necessitating advanced therapeutic interventions. Traditional therapeutic avenues encompassing surgical resection, radiotherapy, and chemotherapy have yielded unsatisfactory clinical outcomes [1]. The infiltrative nature intrinsic to brain tumours impedes comprehensive eradication via surgical intervention, while the impervious blood-brain barrier (BBB) significantly diminishes drug penetration, thereby undermining therapeutic efficacy.

Keywords: Immunotherapy; Nanomedicine; Bilosomes; Brain Cancer

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