HPV Genotype Distribution and Correlation with Age in Women Before and After Leep- Conization and Evaporation in a Single Hospital in Japan

Authors: Niwa K*, Takenaka M, Isobe M, Hayasaki Y, Nagata K, Mori S, Kuwabara K, Niwa K and Tanaka T

DOI: 10.23880/cprj-16000170

Volume 7, Issue 1

Abstract

Persistent infection with high-risk (HR) human papillomavirus (HPV) is the major cause of uterine cervical cancer. Most Japanese women have not been vaccinated. The aim of the present study was to assess the prevalence of HPV genotypes and the relationship between HPV genotype and age in cervical intraepithelial neoplasia (CIN) in Japan. Also, we aimed to clarify the HR- HPV clearance and persistence status after loop electrosurgical excision procedure (LEEP) and evaporation. In LEEP and evaporation cases, HPV tests were examined at 1.5 and 6 months later. Of 1070 CINs, 111 were positive for HR-HPV (10.3%). The ratios of HR-HPV and highly progressive HPV in CIN2+ patients in their 20’s and 30’s were significantly higher than those in patients in their 60’s and 70’s. Forty-seven CIN2+ patients were treated with LEEP and evaporation. Twentyseven of these patients (57.4%) were negative for HR-HPV at 1.5 months later and 37 (78.7%) were negative 6 months later. The ratios of HR-HPV in CIN2+ patients in younger patients were significantly higher than those in elder. Adding evaporation to LEEP tended to improve the HPV elimination rate.

Keywords: HPV; CINs; LEEP-conization; Evaporation

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