HBV Covalently Closed Circular DNA Targeting by Plant Derived Chemical Agent Exploring the Potential of Coumarins

Authors: Tyagi P, Saini AK and Kumar J*

DOI: 10.23880/mjccs-16000338

Volume 7, Issue 3

Abstract

Hepatitis B virus (HBV) infection remains a global health concern, with persistent covalently closed circular DNA (cccDNA) hindering curative treatments. Coumarin is one of these natural compounds that could be utilized as a pharmaceutical agent due to its stability, solubility, availability and low toxicity. Previous studies demonstrate their efficacy, but the challenges of specificity and resistance remain unexplored. Further research is needed to unlock coumarins full potential as antiviral agents for chronic HBV infection and removal of cccDNA from infected hepatocytes.

Keywords: Hepatitis B Virus; HBV cccDNA; Chronic HBV infection; coumarins; Antiviral Therapy; Combination Therapy

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