ISSN: 2993-8260
Authors: Tootoonchi P*
Common variable immune deficiency (CVID) is among the most primary immune deficiency disorders with unknown etiology which mostly presents in adulthood; however, some patients might show their symptoms during childhood. CVID usually increases predisposition to malignancies. Lymphoproliferative malignancies such as lymphoma are the most incident malignancies among the patients; however, the prevalence of Hodgkin lymphoma (HL) is low among the patients and just a few cases of the disorder reported in children. A 13 year old girl admitted to our ward with bilateral cervical lymphadenopathy has emerged since 13 months ago without any associated symptoms. She was a known case of CVID diagnosed at 1 year of age and was under regularly treatment of monthly IVIG and prophylactic antibiotic since then. The diagnostic approach to her lymphadenopathy led to HL diagnosis and she has undergone the standard chemotherapy protocol for HL which took about 6 months without any radiotherapy and showed complete remission. After 6 years of standard follow ups, she is still in complete recovery. To our knowledge, this report seems to be the tenth case of HL emergence in patients diagnosed with CVID during their childhood and the second case of HL emergence despite regularly receiving of monthly IVIG. Low stage of her HL (2A) and favorable response to the chemotherapy with prolong remission might be explained by the regularly prescription of IVIG since early stages of life; albeit these conclusions need to be approved with further studies in the future cases.
Keywords: Hodgkin Lymphoma; Child; Common Variable Immunodeficiency; Lymphoma Malignancy; Primary Immune Deficiency
