ISSN: 2576-4772
Authors: Nagpal N, Kumar N, Ahad Mir P*, Kaur P, Arora M, Kumar A and Priyanka
The goal of this study was to create and test an in vitro floating drug delivery system employing polymers such as sodium carboxymethyl cellulose (CMC Sodium), Xanthan gum (XG), and sodium alginate (SA), using cinnarizine hydrochloride (CNZ) as the model drug. The efficacy of the model drug was proven during the pre-formulation research. 18 distinct formulations were developed using a direct compression (effervescent) technique (F1-F18). As a gas generator, sodium bicarbonate was employed. Physical properties such as weight variation, hardness, friability, floating lag time, and total floating duration were assessed in all of the formulations. Four mathematical models were used to predict the drug release Kinetics: zero order, first order, Higuchi, and Korsmeyer Peppas. F1, F2, F3, F6, and F7 were known to be the optimum formulations. They all include the same amount of sodium bicarbonate (40 mg) and ethyl cellulose (40 mg), but different quantities of CMC Sodium, XG, and SA (150mg, 120mg, 90mg, 150mg and 120mg of CMC Sodium:30mg, 60mg, 90mg, 0mg, 0mg of XA & 0mg, 0mg, 0mg, 30mg and 60mg of SA respectively). In 0.1N HCl, all of the optimized batches had a release rate of 92 % to 99.8% in 12 hours and showed adequate swelling for up to 10 hours. Polymers such as CMC sodium, XG, and SA, in conjunction with sodium bicarbonate as a gas producing agent, may be employed to formulate sustained release floating tablets containing CNZ, according to the findings.
Keywords: Floating Drug Delivery System; CMC Sodium; Xanthan Gum; Sodium Alginate; Cinnarizine Hydrochloride; Sustained Release
