ISSN: 2574-187X
Authors: Nemuri M, Vyshnavi M and Pancheddula M*
The primary objective of this work was to create and evaluate Itraconazole-loaded nanoparticles using the ionic gelation process to improve their solubility and bioavailability. Ionic gelation was used to prepare Itraconazole nanoparticles, which are classified as a BCS class II drug. These particles were then characterized using techniques such as Fourier transform infrared spectroscopy, differential scanning Calorimetry, powder X-ray diffraction, scanning electron microscopy, zeta potential, and in-vitro drug release studies. There was no evidence of contact between the drug and the polymers based on the differential scanning Calorimetry results, powder X-ray diffractometry, and Fourier transforms infrared spectroscopy. Nano particulate formulation prepared with Chitosan in 1:6 ratio showed satisfactory results i.e. average particle size 201.67 nm, polydispersity index 0.111, zeta potential -46.2 mV, and entrapment efficiency 89.04%. FTIR study concluded that no major interaction occurred between the drug and polymers used in the present study. This technology on a laboratory scale and this strategy could be used to improve the solubility and bioavailability of BCS class II medications.
Keywords: Itraconazole; Ionic Gelation Method; Chitosan; BCS Class II Drug; Nanoparticles
