ISSN: 2577-4360
Authors: Brou EC*, Kipre GR, Yayo SED and Bidie AP
Diabetic Kidney Disease (DKD) is the most common cause of the end stage renal disease worldwide. The gold standard for the early detection of this disease is the urinary albumin creatinine ratio (ACR). However, a significant proportion of people with type 2 diabetes have renal failure while remaining normoalbuminuric. This study aimed to evaluate the utility of cystatin C (cys C), as an early biomarker of renal impairment among Ivorian type 2 diabetics. Serum and urinary creatinine, serum glucose, albuminuria and serum cystatin C were determined in 50 diabetic patients. The glomerular filtration rate (eGFR) was estimated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation and the ACR was calculated. A Receiver Operating Characteristic (ROC) analysis was applied. Among normoalbuminuric patients, the cys C level in patients with lowered eGFR was statistically higher than those with normal eGFR. Moreover cystatin C was well correlated with eGFR (r= -0,74, P < 0,001). The Receiver Operating Characteristic (ROC) curve analysis, in normoalbuminuric patients with eGFR less than 90 ml/min/1.73 m2 GFR as reference, revealed an area under the curve (AUC) of 0,89 (95%). Serum cystatin C could help for early detection of diabetic kidney disease in support of urinary albumin, especially in normoalbuminuric patients with type 2 diabetes in Cote d’Ivoire.
Keywords: Albumin; Nephropathy; Serum Cystatin C; Type 2 Diabetes
