SKP1-Cullin1-F-Box Complex in Chronic Inflammation-Associated Tumorigenesis

Authors:

Prateeti S^1,2 and Chang SC^1*

DOI: 10.23880/oajco-16000110

Volume 1, Issue 2

Abstract

In SKP1– cullin 1–F-box protein (SCF) E3 ligase complexes, F-box proteins are main subunits responsible for substrate-recognition. F-boxes play vital roles in several cellular processes through ubiquitylation and consequent degradation of target proteins. Due to dysregulation of F-box protein-mediated proteolysis, it leads to many diseases. In this review, we give the important roles of F-box proteins and its family members in the regulation of many cellular activities.

Keywords:

F-box; Ubiquitin-Proteasome system; Cancer Formation; Inflammation

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