Synthesis Anti Inflammatory and Antimicrobial Evaluation of Novel 2 phenyl 3 4 phenylthiazol 2 yl amino thiazolidin 4 One Derivatives

Authors: Mudgil S, Kumar M, Lamba P, Nehra B* and Rani P

DOI: 10.23880/oajpr-16000287

Volume 7, Issue 3

Abstract

In order to explore the therapeutic potential of thiazolidinone based analogues, five novel 2-phenyl-3-((4-phenylthiazol-2-yl) amino)thiazolidin-4-one derivatives (7a-e) were synthesized using multistep synthetic methodology. Structural elucidation of all synthesized molecules was performed by using IR and 1H NMR spectral reports. All molecules were accessed for their anti-microbial potential against a panel of four bacterial strains and one fungal strain. Results of in vitro antimicrobial data revealed compounds 7c and 7d as most potent antibacterial agent towards E. coli, S. aureus and B. subtilis with MIC values of 6.25 µg/mL while Compounds 7a, 7b and 7e as most active antifungal agents against tested fungal species i.e., R. oryaze (MIC = 3.125 µg/mL). Further, in vitro anti-inflammatory potential was evaluated for synthesized molecules in which compound 7d have powerful anti-inflammatory profile with IC50 value of 1.27 µg/Ml.

Keywords: 4-Thiazolidinone; Antimicrobial; Anti-Inflammatory; Heterocyclic; Thiazole

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