Exiguous and Scarce-SMARCB1 Deficient Medullary Renal Cell Carcinoma

Authors: Bajaj A*

DOI: 10.23880/cclsj-16000188

Volume 8, Issue 2

Abstract

Switch / sucrose non fermentable (SWI/SNF) related, matrix associated, actin dependent regulator of chromatin subfamily B member 1 (SMARCB1) deficient medullary renal cell carcinoma is an exceptionally discerned, aggressive carcinoma associated with deficiency of SMARCB1 or integrase interactor 1(INI1). Neoplasm is associated with sickle cell trait or various sickle cell haemoglobinopathies wherein appearance of sickle shaped erythrocytes or drepanocytes may be pathognomonic. Tumefaction preponderantly arises within young subjects with sickle cell trait. SMARCB1 deficient medullary renal cell carcinoma demonstrates diverse histological configurations. Prognostic outcomes are inferior. Previously denominated as unclassified renal cell carcinoma with medullary phenotype and additionally designated as SMARCB1 deficient renal medullary carcinoma or renal medullary carcinoma, tumefaction is characteristically confined to renal medulla.

Keywords: SMARCB1; Deoxyribonucleic Acid; Medullary Renal Cell Carcinoma; Neoplasms; Sickle Shaped Erythrocytes

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