Potential of Sulforaphane to Ameliorate the Deleterious Effects of Monosodium Glutamate on Spermatic Vitality and the Histological Architecture of Seminiferous Tubules Antioxidant Mediated Pathway

Authors: Ahmed S Ahmed*, Liju S Mathew, Marwa M Mona, Omaima K Docmac, Hoda A Ibrahim, Amira AL Shamy, Rasha A Elsisy and Ehab M Hantash

DOI: 10.23880/jhua-16000181

Volume 7, Issue 1

Abstract

Sulforaphane (Sf) is found abundantly in raw vegetables with a potent antioxidant potential. Several studies had reported the harmful effects of monosodium glutamate (MG) on the histological structure of testis and semen quality. This study was established to study the potential of Sf to protect the spermatic vitality and the histological architecture of seminiferous tubules from the deleterious effects of MG. Forty albino rats were used and were separated into 4 groups that received Sf and MG supplementations. Sf was found to ameliorate the deleterious action of Sf on spermatic vitality and motility. Sf showed its potential to restore the sex hormones levels and to enhance antioxidant markers, in addition, to preserve the histological architecture of the testis after administration of MG. In conclusion, Sf plays a crucial role in protecting the testicles on a functional and histological dimension.

Keywords: Sulforaphane; Monosodium Glutamate; Semen; Antioxidant; Sex Hormones

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