ISSN: 2577-4379
Authors: Cobar O*
Introduction: The proteins codified in the Open Reading Frame 1ab -Orf1ab- region of the SARS-CoV-2 genome triggers the virus transcription, replication, and translation processes inside the human cell. Targets: The purpose of the Mini Review is to present a systematic review as of October 31, 2023, on the Orf1ab region mutations of the SARS-CoV-2 genome, with the aim to predict, through the mutations profile on that region, the severity of an infection for a new SARS-CoV-2 variant that could emerge in the near future. Method: Original scientific articles published in Medline, Pubmed, Science Direct, Web of Science, Scopus, EBSCO and BioMed Central databases, official health organizations (WHO, CDC, ECDEC, NIH) electronic publications, and specialized media in the subject, were electronically searched to accomplish the aim of the study. Results: The search on scientific literature on Orf1ab SARS-CoV-2 genome region together with the analyses of the specific mutations, can be an invaluable tool for predict virus variants pathogenicity. Conclusions: The analyses of Orf1ab genome mutations, allows us to predict, through the mutations profile on that region, the severity of an infection for a new SARS-CoV-2 variant that could emerge in the near future. Outlook: As clearly illustrated, the pathogenicity of actual and future SARS-CoV-2 variants can be predicted.
Keywords: SARS-CoV-2 Genome; Open Reading Frame; Orf1ab; Non-structural Proteins; RNA-Dependent RNA Polymerase (RdRp); Main Protease (MPro); Helicase
