The Role of VGLL4 in Development and Progression of Tumors

Authors: Zhang H, Zhong Y, Chen H and Yu W*

DOI: 10.23880/act-16000288

Volume 8, Issue 4

Abstract

The Hippo pathway plays an important role in controlling the size of organs, as well as cell proliferation, apoptosis and tumor formation. VGLL is a recently discovered family of proteins that can interact with TEAD, a transcription factor downstream of the Hippo pathway, and is an important regulatory factor in tumorigenesis. Unlike other members of the VGLL family, VGLL4 contains two TDU domains that can compete with YAP to bind TEADs to inhibit the transcriptional function of YAP. Overexpression of VGLL4 can inhibit malignant transformation of cells and is considered a tumor suppressor. VGLL4, as a transcriptional cofactor of the Hippo pathway, is involved in regulating the occurrence and development of tumors. Further studying the role and mechanism of VGLL4 in Hippo and other tumor-related pathways in the development and progression of cancer will provide new ideas for the prevention and treatment of human tumors.

Keywords: Hippo pathway; VGLL4; Tumor; Cancer

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