ISSN: 2476-2490
Authors: Avramov T*
Introduction: The COVID-19 pandemic has changed the way we live and put health systems and economics around the world under stress. It caused about 598 million cases and resulted in about 6.4 million deaths worldwide. In recent decades, we have seen extraordinary progress in the field of biomedical knowledge as well as in the study of emerging new viral pathogens. New outbreaks of infection in different geographical areas have led to the isolation of a large number of highly pathogenic viruses belonging to the families Filoviridae, Arenaviridae, Bunyaviridae, Paramyxoviridae, Coronaviridae, Flaviviridae, Togaviridae and Hepeviridae, which have a zoonotic origin. Zoonoses are diseases transmitted from animals to humans and pose a serious threat. The development of protective and therapeutic measures against the spread of SARS-CoV-2 is an important part of tackling the problem, but only when we clarify the interrelationship in the interaction between viral and bacterial pathogens, the human microbiota, immunity and our way of life. Conclusion: Infectious diseases are among the strongest causes of selective pressures driving human evolution. Understanding the possible interactions between viral and bacterial pathogens on the one hand and the human microbiota and genome will allow us to correctly use pharmacological, non-pharmacological and dietary interventions to predict and control the risk in the course of such diseases. Genetics in the coming decades will likely allow us to identify loci characterizing the genetic variation of immune-related genes to understand the dynamics of human immunity formation. Adopting a One health approach to public health is of great importance. The human population is only a small, albeit important, part of the Earth's ecosystem. The relationship between human health and animal health must be taken into account, as was suggested to us during the last pandemic.
Keywords: SARS-COV-2; Zoonoses; Prebiotics; Probiotics; Prevention; Interactions; Cocirculating Pathogens; Microbiota; Human Genom
