Semaglutide, a GLP-1 Agonist Like 'Ozempic' and its Potential Role as a Preventive Anti-Cancer Agent

Authors: Maher M. Akl* and Amr Ahmed

DOI: 10.23880/cclsj-16000195

Volume 9, Issue 1

Abstract

This research note explores the potential of Semaglutide, a GLP-1 agonist similar to Ozempic, as a preventive anti-cancer agent. It discusses shared pathophysiological features between cancer and diabetes, including insulin resistance, inflammation, oxidative stress, and adipokine imbalance. The note highlights GLP-1's role in diabetes prevention, its mechanisms, and ongoing research. It also touches upon the promising relationship between GLP-1 receptor agonists and cancer treatment, focusing on their impact on cell proliferation, apoptosis, and angiogenesis regulation. Finally, it emphasizes the importance of establishing optimal dosages for GLP-1 agonists and their potential to address both diabetes and cancer prevention.

Keywords: Semaglutide; Cancer; Diabetes; Adipokine Imbalance; Glucose Transporter 4 (GLUT4); Interleukin-6 (IL-6); GLP-1 Receptors

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