Neutrophil Responses in Gestational Diabetes: A Cellular Ballet

Authors: Emmanuel Ifeanyi Obeagu* and Getrude Uzoma Obeagu

DOI: 10.23880/hij-16000230

Volume 8, Issue 1

Abstract

Gestational diabetes mellitus (GDM) introduces distinctive challenges to the maternal immune system, orchestrating a complex interplay with the pivotal cellular dancers, neutrophils. This review delves into the dynamic world of neutrophil responses during gestational diabetes, portraying a cellular ballet influenced by factors such as oxidative stress, cytokine modulation, and their repercussions on both maternal and fetal health. The review amalgamates existing literature to provide a nuanced understanding of the intricate dance of neutrophils in the context of gestational diabetes. The review delves into the unique cellular dynamics at the maternal-fetal interface, shedding light on how neutrophils contribute to the immune homeostasis crucial for a healthy pregnancy. The article concludes by discussing clinical implications and potential therapeutic strategies to navigate the intricate cellular ballet, offering insights for future research and intervention in the realm of gestational diabetes and immune modulation during pregnancy.

Keywords: Gestational diabetes mellitus, Neutrophil, Cellular ballet, Oxidative stress, Inflammation, Maternal immune system

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