ISSN: 2578-501X
Authors: Emmanuel Ifeanyi Obeagu* and Getrude Uzoma Obeagu
Hemolysis in pregnancy represents a complex and multifaceted challenge, particularly for individuals grappling with sickle cell anemia. This review delves into the intricate interplay between the physiological changes induced by pregnancy and the underlying pathophysiology of sickle cell anemia. It provides a comprehensive examination of the clinical implications, management strategies, and recent research advances pertaining to hemolysis in pregnant women with sickle cell anemia. The physiological adaptations inherent in pregnancy, including alterations in the cardiovascular and hematologic systems, create a dynamic environment that may exacerbate hemolysis in individuals with sickle cell anemia. This review elucidates the intricacies of these changes, establishing a foundation for understanding the heightened risks and challenges faced by pregnant women with this inherited blood disorder. Effective management strategies are crucial for optimizing outcomes in pregnant women with sickle cell anemia experiencing hemolysis. This review provides an in-depth analysis of various approaches, including the role of hydroxyurea therapy, blood transfusions, and meticulous monitoring of maternal and fetal parameters. By evaluating the potential benefits and risks of each strategy, clinicians are equipped with valuable insights to tailor interventions to individual patient needs. In conclusion, this comprehensive review offers a synthesized perspective on the considerations surrounding hemolysis in pregnancy for individuals with sickle cell anemia. Bridging the realms of physiology, clinical practice, and research, it provides a valuable resource for healthcare professionals, researchers, and policymakers seeking to enhance the care and outcomes of pregnant women grappling with sickle cell anemia and heightened hemolytic challenges.
Keywords: Hemolysis; Pregnancy; Sickle Cell Anemia; Physiological Changes; Maternal Health; Management Strategies
