ISSN: 2642-6250
Authors: Maqbool M and Willie MM*
The emergence of antibiotic resistance presents a serious worldwide health challenge, rendering previously effective treatments ineffective and imposing significant hurdles on global healthcare systems. This comprehensive examination delves deeply into the intricate realm of antibiotic resistance, investigating its mechanisms, catalysts, and repercussions, while also delving into innovative therapeutic methodologies that propose potential remedies. The mechanisms that underlie antibiotic resistance encompass genetic mutations, horizontal gene transfer, and efflux pumps, enabling bacteria to adapt and persevere when exposed to antibiotics. These mechanisms, when combined with the widespread mishandling and overuse of antibiotics in both human and animal contexts, have facilitated the rapid proliferation of pathogens resistant to multiple drugs. The global reverberations of antibiotic resistance are extensive, encompassing amplified mortality rates, prolonged hospitalizations, and escalated healthcare expenses. Elements such as subpar infection control protocols and international travel contribute to the dissemination of these resistant strains, extending beyond geographic and healthcare boundaries. Given the scarcity of novel antibiotic advancements, addressing antibiotic resistance necessitates novel therapeutic methodologies. This multifaceted challenge requires immediate action. Employing pioneering therapeutic methods alongside judicious antibiotic application can counteract antibiotic resistance and ensure the availability of effective treatments for generations to come.
Keywords: Antibiotic; Resistance; Novel Therapy; Gene Transfer
