Cytotoxic and Anti-Cervical Cancer Effects of the Camellia sinensis Byproducts from Various Kenyan Factories

Authors: Thaddeus M, Daniel K, Johnson K, Martin O, Simon O and Gervason M*

DOI: 10.23880/oajpr-16000297

Volume 8, Issue 1

Abstract

Cervical cancer is a significant global health challenge and necessitates the search for innovative and patient-friendly therapies due to the limitations and challenges posed by conventional treatments. This study explored the largely overlooked potential of Camellia sinensis processing wastes as a natural source for developing effective and safe anticancer compounds. Tea waste samples from Kenyan processing facilities demonstrated concentration-dependent cytotoxic effects on normal epithelial cells (Vero), with the fluff sample from Chelal displaying superior efficacy. Median inhibitory concentration (IC50) values highlighted the potency of the samples, especially the fluff sample from Chelal (IC50: 483.99μg/ml). Selectivity indices revealed favorable safety profiles, indicating selective potential anticancer effects against cervical cancer cells. This study contributes substantively to understanding tea waste’s anticancer potential, providing valuable insights for drug development. The study offers a foundation for continued research into sustainable and impactful anticancer drug discovery, emphasizing specific results that pinpoint promising tea waste samples and their potential applications in cervical cancer therapy and anticancer drug development

Keywords: MTT assay; Tea fluff; Cyclone fluff; HeLa cell line; Vero Cell line; IC50

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