Development Design and Evaluation of a Polyherbal Topical Cream for the Management of Melasma

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DOI: 10.23880/ipcm-16000267

Volume 8, Issue 1

Abstract

The aim of this research was to formulate and evaluate an herbal cream for the treatment of melasma containing prunus dulcis, poppy seed and cucumis sativus seeds. Melasma is a common skin problem mostly found in women. The condition causes discoloured dark patches on the skin. It is also called as chloasma, or the “pregnancy mask,” it commonly occurs in pregnant women. The condition is much more common in women than men, though men can get it too. In this study almond prunus dulcis, family rosaceae, poppy seed and cucumber, cucumis sativus seeds, family cucurbitaceae all the three were extracted separately with ethanol by maceration method. The ethanolic extracts were incorporated together to formulate a cream. The formulated cream was evaluated for pH, viscosity, spreadability, extrudability, stability, antimicrobial activity and skin irritation test. The pH and spreadability index were found to be the excellent, the stability was carried out in a stability chamber for 30 days with varying temperatures, and the product did not show any phase separation. The Polyherbal cream was free from microbial growth and there was no erythema or edema after skin irritation study. Hence a Polyherbal cream containing prunus dulcis, poppy seed and cucumis sativus seeds were prepared and evaluated for the treatment of melasma. The prepared cream can be an efficacious product for the treatment for melasma.

Keywords: Antimicrobial; Antifungal; Melasma; Polyherbal Cream

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