Role of Cytokines in Behcets Disease

Authors:

Abdelmoktader A*

Volume 1, Issue 4

Abstract

Behcets disease (BD) is considered a chronic relapsing multisystem inflammatory disorder. It has a worldwide distribution, but it is more prevalent in Mediterranean countries. Although its etiopathogenesis remains elusive, Immunological investigations have demonstrated the presence of immune dysregulation among the patients with BD. The disease is characterized by infiltration of lymphocytes and neutrophils into the affected organs.the Th1 type cytokine profile is predominant in. The serum concentrations of mainly Th1 type cytokines were reported to be increased in BD and probably contribute to neutrophil and endothelial cell activation.

Keywords:

Behcets disease; IL-1 gene family; TNF-α; Th17; IL 17; IL 23; Th1; IFN-γ; IL12; IL 18; Th2; IL6; IL10

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