ISSN: 2640-2726
Authors: Hameed Rekani*, Zozan Faris and Nazdar Raouf
Background: Maternal antibodies that interact with both maternal and fetal platelets cause autoimmune thrombocytopenia. This happens in autoimmune diseases of the mother, such as immune thrombocytopenia purpura (ITP). Objective: The aim of the study was to evaluate the treatment and prognosis of newborns whose mothers had ITP. Methods: A multi center prospective study was carried out at the Duhok Obstetrics and Gynaecology Teaching Hospital and Kurdistan Private Hospital in Iraqi Kurdistan between November 2016 and November 2022. The requirements for inclusion were all expectant mothers with verified ITP diagnoses. Every newborn was monitored in the neonatal intensive care unit and had their thrombocytopenia assessed on their first day of life. Maternal age, parity, diagnosis time, history of previous splenectomy, platelet count at delivery and in the early stages of pregnancy, propensity for bleeding throughout pregnancy, treatment for ITP, and method of delivery based on obstetric circumstances were all noted. the baby's gender, gestational age at delivery, the neonatal platelet count at birth, haemorrhage, and thrombocytopenia therapy. Nominal variable statistics were expressed. Results: 25 neonates delivered by pregnant mothers with ITP during the trial period were all included in the analysis. The ITP patients' mothers were between 23 and 33 years old. There were 14 (56%) multigravida cases and 11 (44%) primigravida cases. Prior to three years of pregnancy, just one (4%) instance had a history of splenectomy. The mother's platelet count at delivery was less than 50 × 109/L in 7 (28%) cases. Thirteen (52%), utilised corticosteroids. Ten (40%) of the deliveries were caesarean sections. Two (8%) cases had gestational ages between 33 and 36.6 weeks, whereas 23 (92% of cases) had gestational ages between 37 and 38 weeks. In 12 (48%) cases, the birth weight ranged from 1200 to 2500 kg, whereas in the other cases, it was between 250 and 3300) kg in 13(52%) cases the new-born baby's gender was male. Twelve (48%) of the newborns had thrombocytopenia. Just three cases (about 25%) needed medical attention. Conclusion: Pregnancy counselling is necessary for a woman with a history of ITP in order to maximise her platelet count. While serious bleeding is uncommon in neonates with maternal ITP. Corticosteroids are an effective therapeutic option for both the mother and the new-born
Keywords: Immune Thrombocytopenia Purpura; Corticosteroid; Neonatal Thrombocytopenia
