ISSN: 2574-7797
Authors: Ajay RN*, Ravindra K, Rohan K, Rupali G, Rohini C, Ravindra D, Purva K, Gadhave R and Rushikesh K
This study focuses on the formulation development and evaluation of mouth dissolving films (MDFs) containing taurine, an amino acid with potential therapeutic benefits. Taurine-loaded MDFs were formulated using hydroxypropyl methylcellulose (HPMC) E5 as the polymer, polyethylene glycol 400 (PEG 400) as the plasticizer, and sucrose as the sweetening agent. Additional ingredients included menthol for flavoring and citric acid for saliva stabilization. The formulations were evaluated for various parameters including physical appearance, thickness, weight variation, surface pH, in vitro disintegration time, folding endurance, drug content, and in vitro drug release. Results demonstrated uniformity, flexibility, and rapid drug release, with formulation F5 exhibiting the highest drug content and desirable properties. Future perspectives include exploring therapeutic applications, personalized medicine, and regulatory approval for clinical use. This study highlights the potential of taurine MDFs as a patient-friendly dosage form with promising therapeutic efficacy.
Keywords: Taurine; Mouth Dissolving Films; Formulation & Development; Evaluation; Drug Delivery
