A Review on Formulation and In-Vitro Evaluation of Sustained Release Tablet of Isoniazide by Using Natural and Synthetic Polymer

Authors: Rutuja N*, Piyush B, Mansi P, Tushar N, Yogesh S, Dhanajay P

DOI: 10.23880/oajpr-16000308

Volume 8, Issue 2

Abstract

The goal of this study was to combine many polymers to create an isoniazide tablet with a sustained release. In this piece of work, guar gum, xanthum gum, and eudragit L100 are the polymers employed. The FTIR and UV analyses suggested that there was no bond formation between the medication and the polymer. The DSC results rejected any association or complex arrangement between the drug and the polymer that released the drug. This involves determining the drug's melting point, evaluating its solubility, and analysing it with a UV spectrophotometer. The definitions were established using a variety of assessment characteristics, such as Angle of repose, Bulk Density, Hardness, Friability, and Drug content uniformity

Keywords: Isoniazid; Eudragit L100; Xanthum gum; Guar Gum

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