ISSN: 2578-501X
Authors: Emmanuel Ifeanyi Obeagu* and Getrude Uzoma Obeagu
This paper explores the intricate interplay between HIV infection, severe malaria, and blood transfusion in pediatric patients. With a focus on the immunomodulatory effects of blood transfusion, we delve into the complex dynamics that govern these overlapping health challenges. This review aims to contribute to a nuanced approach to care, fostering improved outcomes and better-informed healthcare decisions for HIV-positive pediatric severe malaria patients requiring blood transfusion. The immunopathogenesis of HIV and severe malaria sets the stage for understanding the unique vulnerabilities of coinfected children. Blood transfusion, a critical intervention for severe anemia, is examined in the context of its impact on immune responses in HIV-positive pediatric severe malaria patients. The paper synthesizes existing knowledge on transfusion-related immune modulation (TRIM) and navigates through challenges and controversies surrounding this therapeutic strategy. Future perspectives and recommendations underscore the need for further research to enhance our understanding and guide clinical practice in managing this complex patient population.
Keywords: Immunomodulatory Effects; Blood Transfusion; HIV; Pediatrics; Malaria Plasmodium Falciparum
