Impact of Modified Vesicular Drug Delivery Systems on Polyherbal Formulations for Challenging Ailments

Authors: Sumathi A* , Suriyaprakash TNK , Lakshmana Prabu S and Balan P

DOI: 10.23880/beba-16000109

Volume 1, Issue 2

Abstract

Herbal plants have enormous therapeutic potential which should be explored through the fabrication these drugs in novel drug delivery systems. The major limiting factors viz. lipid solubility and molecular size of the phytoconstituents to pass the biological membrane can be overcome by the usage of novel carriers. Also, the concept of multi-targeted therapy exists in traditional system of medicine. These multi-components existing in the extracts of natural products act simultaneously on multiple targets. Thus, polyherbal therapies involve the combination of various types of agents from different plant sources and thereby used to enhance therapeutic efficacy. They also minimize the risk of development of drug resistance. Standardized plant extracts when administered through novel drug delivery system show much better pharmacodynamic and pharmacokinetic profile. Hence more amount of active constituent becomes available at the site of action at same or lesser dose compared to the conventional plant extract. Hence, the therapeutic action becomes enhanced, more detectable and prolonged. Several excellent phytoconstituents have been successfully delivered using NDDS. Hence, this review is focused on the potential of novel drug delivery systems in the development of plant actives and extracts.

Keywords: Herbal plant; Polyherbal; NDDS; Phytoconstituents; Phytosomes

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