ISSN: 2576-7771
Authors: Anas Abdullah Hamad*
The biofilm and its effects on humans and animals are critical topics to investigate. The first step in treating biofilm with neutral or medicinal plant extracts is to understand the mechanisms of action and how these extracts target the biofilm bacterial species. According to the most up-to-date research, medicinal plant extracts offer a wide range of biological potential, involving antioxidant, antibacterial and anti-inflammatory effects. Biofilm formation occurs in several stages involving attaches to the surface, develops an irreversible matrix, begins to form and releases the balance, and then initiates a new cycle. Quorum sensing (QS) is a mechanism through which bacteria communicate among each other through using tiny molecules. The main mechanisms by which natural products inhibit the development quorum sensing networks and biofilms are by suppressing cell adhesion, stopping the production of extracellular matrix, and reducing synthesis of variance factors. The ability of plant extracts to act as resistance modifying agents is a promising field in preventing the spread of bacterial resistance. The information in this review article was gathered from scientific articles indexed in databases such as PubMed, Scopus, ISI and Google Scholar from 2001 to 2022.
Keywords: Biofilm Formation; Efficacy of Plant Extracts; Bacterial Resistance
