Alterations of Glucocorticosteroids Thyroid Hormones Leptin and Endothelins Threat of Cardiovascular Disease in Diabetes

Authors: Williams CE, Nwanguma E, Nnodim JK*, Ibanga EI, Ihim A and Nwaokoro JC

DOI: 10.23880/mjccs-16000366

Volume 8, Issue 2

Abstract

Background: The cardiovascular diseases are phenomenon or circumstances that affect the structures as well as function of the heart. Aim: The level of glucocorticosteroids, thyroid hormones, leptin, and endothelins in cardiovascular subjects was determined in Owerri, Imo state. Method: A total of 100 subjects within the age 35-65 years were recruited for this study. The study consists of 50 subjects who were diagnosed of cardiac disorders and 50 were apparently healthy individuals who served as controls subjects of the same age bracket. The levels of glucocorticosteroids, thyroid hormones, leptin, and endothelins were analysed using ELISA technique. Data was assessed using SPSS version 20, the mean value with P˂ 0.05 was considered statistically significant. Results: The result revealed that the levels of glucocorticosteroids, thyroid hormones, leptin, and endothelins in cardiovascular disorder were significantly increased when compared with control subjects. Conclusion: The increased serum level of glucocorticosteroids, thyroid hormones, leptin, and endothelins in cardiac malfunction subjects may contribute some risk factors in patients with cardiac dysfunction and in people living with diabetes.

Keywords: Glucocorticosteroids; Thyroid Hormones; Leptin; Endothelins; Cardiovascular Disease; Diabetes

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