Targeting Superbugs: Efficacy of Bacteriophage Therapy against Antibiotic-Resistant Pseudomonas Aeruginosa in Urinary Tract Infections

Authors: Hashir Khan, Wajiha Sajjad

DOI: 10.23880/aemb-16000129

Volume 6, Issue 1

Abstract

The rise of antibiotic-resistant bacterial infections poses a significant challenge to global health, particularly in the treatment of urinary tract infections (UTIs). This study evaluates the potential of bacteriophage therapy as an alternative treatment against antibiotic-resistant Pseudomonas Aeruginosa isolated from UTI samples. We isolated 12 strains of P. aeruginosa from 50 UTI samples and conducted extensive antibiotic susceptibility testing, revealing significant resistance to multiple conventional antibiotics such as Tetracycline, Septran, Ceftazidime, and Cefepime, while showing susceptibility to Imipenem and Meropenem. Concurrently, we isolated and characterized bacteriophages from sewage samples that demonstrated specific lytic activity against the antibiotic-resistant strains. Our findings suggest that bacteriophage therapy provides a high specificity and efficacy in targeting antibiotic-resistant P. aeruginosa, offering a promising alternative to traditional antibiotic therapies. This study underscores the potential of phages in clinical applications, advocating for further clinical trials and the development of a regulatory framework to integrate phage therapy into mainstream medical practice for combating antibioticresistant infections.

Keywords: Bacteriophage Therapy; Antibiotic-Resistant; Urinary Tract Infections

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