Sudden Death Associated with Propofol Infusion Syndrome

Authors: Ng MJ, Morozov YE*, Lisovskaya SB, Morozov SY, Ng CC and Bashilov AA

DOI: 10.23880/ijfsc-16000391

Volume 9, Issue 2

Abstract

In forensic practice, PRIS is considered as the comorbid disease. The project was devoted to the study of PRIS signs in 38 cases of sudden death after surgical interventions. Archival forensic material of “medical cases” for the period from 2011 to 2020 was studied. The clinical and laboratory features of PRIS are summarized. It was found that the most common symptoms were lactic acidosis, hyperkalemia, and progressive heart failure. Optimization of standard forensic chemical study was carried out, in which it was established that the hydrolysis stage must be included in the urine sample preparation procedure for the determination of propofol. When conducting forensic chemical study of biological objects for the content of propofol, the analytical technologies used must have the sensitivity for detecting propofol in the blood at the level of 0.01 μg/ml or lower. Solid-phase extraction method on cartridges with mixed hydrophobic-anion exchange properties with sorbent such as Oasis MAX Cartridge 3cc, /60 mg/60μm companies Waters (USA) is 17% more effective than the routine liquid-liquid extraction method of propofol from blood. The preparation of TMS derivatives of propofol, increases the efficiency of chromatographic separation and provides the possibility for the analytical study of extracts from blood over a longer period of time (up to 24 hours).

Keywords: Propofol; Sudden Death; Propofol Infusion Syndrome; Lactic Acidosis; Forensic Chemical Analysis

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