ISSN: 2578-4838
Authors: Anubha Bajaj
Hepatocellular adenoma emerges as a benign, solitary neoplasm of hepatocellular origin preponderantly arising within non cirrhotic hepatic parenchyma. Lesion occurs secondary to obesity, metabolic syndrome and consumption of anabolic steroids or non-contraceptive oestrogen supplements. Concurrent to genetic mutations, hepatocellular adenoma is categorized as hepatocellular adenoma associated with HNF1A genetic mutation, hepatocellular adenoma associated with β catenin genetic mutation, inflammatory hepatocellular adenoma, sonic hedgehog (SHH) hepatocellular adenoma or hepatocellular adenoma, not otherwise specified. Cytological assessment exhibits bland, uniform hepatocytes permeated with regular nuclei and decimated nucleocytoplasmic ratio. Tumefaction may display a pseudo-acinar arrangement, foci of steatosis and attenuated, mildly thickened one to two cell thick cell plates with a well-defined perimeter and characteristic unpaired arterial configurations. Hepatocellular adenoma appears immune reactive to HepPar1 or reticulin and immune non-reactive to glypican 3, CD34 or HSP70. Neoplasm requires segregation from neoplasms such as focal nodular hyperplasia, well differentiated hepatocellular carcinoma, mass effect due to an adjacent mass lesion, haemangioma, lymphoma, echinococcal cyst, hepatoblastoma, and localized fatty change or metastatic lesions arising from various primaries, confined to hepatic parenchyma. Hepatocellular adenoma may be appropriately managed with surgical extermination.
Keywords: Hepatic Lesion; Solitary; Unpaired Arterial Structures
