ISSN: 2574-187X
Authors: Shrisha S Raj, Saba Naseem, Bhuvana D, Ruchira R Shetty, Priyanka Dave* and Rosilda Selvin*
Large volumes of titanium dioxide (TiO2) nanoparticles (NPs) are produced globally for a variety of uses. The physicochemical characteristics of TiO2 nanoparticles differ from those of their fine particle (FP) analogues, potentially modifying their bioactivity. The majority of the research included here has addressed the respiratory system and demonstrated the significance of inhalation as the main method of exposure to TiO2 NP in the workplace. TiO2 NPs have the potential to move from the gastrointestinal tract (GIT) and lung to systemic organs, albeit this appears to happen at a slow rate. Additionally, research has been conducted on other human exposure pathways. TiO2 nanoparticulate carriers can be injected intravenously to enter the human body and be used in nanomedicine. Intravenous exposure to TiO2 NPs can result in pathological lesions in the brain, kidneys, liver, and spleen. Additionally, as we have demonstrated here, the majority of these effects might result from the use of extremely high concentrations of TiO2 NPs. Despite the rising manufacturing and usage of TiO2 NPs, there is also a dearth of epidemiological data on this topic. Lung tumors have been documented in long-term rat inhalation trials, however. This study outlines the present state of knowledge about the general and green synthesis methods of TiO2 nanoparticles with applications in medicine.
Keywords: Titanium Dioxide; Nanoparticles; Nanomedicine
