ISSN: 2576-4772
Authors: Adaikala Raj G*, Muthu sheeba M, Gnana Suriya P and Sinthiya N
In this research, investigate the antibacterial properties of various crude extracts obtained from the brown alga Dictyota dichotoma (Hudson) J.V.Lamouroux. Specifically, we analyzed the hexane, chloroform, ethyl acetate, and methanol extracts in detail to assess their effectiveness against a wide range of multidrug-resistant bacterial strains. These strains encompassed Staphylococcus aureus, Bacillus subtilis, Streptococcus pyogenes, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella typhimurium, Vibrio cholerae, Shigella flexneri, Proteus mirabilis, and P. vulgaris, representing a diverse array of challenging pathogens. The assessment of these extracts was conducted via the disc diffusion method, employing varying concentrations (250µg/disc, 500µg/disc, and 1000µg/disc). Notably, the resulting mean inhibition zones ranged significantly, spanning from 8.5 mm to 23.8 mm, indicative of varying degrees of antibacterial activity across the extracts. Complementing this, the determination of minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) further delineated the potency of these extracts, with MIC values spanning from 62.5µg/ml to 500µg/ml, and MBC values from 125µg/ml to 1000 µg/ml. Of particular interest was the ethyl acetate extract derived from D. dichotoma, which exhibited a remarkable mean inhibition zone of 26.5 mm, alongside the lowest MIC (62.5 µg/ml) and MBC (125 µg/ml) values against S. aureus. This compelling finding underscores the potential of D. dichotoma as a reservoir for novel antibacterial compounds with efficacy against multidrug-resistant bacterial strains. Such insights illuminate promising avenues for the development of innovative therapeutic interventions targeting antibiotic-resistant pathogens.
Keywords: Bombax Ceiba; Phytochemistry; Pharmacological Activities; Medicinal Uses
