ISSN: 2476-2490
Authors: Avramov T*
Introduction: Our body hosts a complex microbial community [microbiota] responsible for its development, optimal functioning and health. We are constantly witnessing the emergence of new diseases caused by a large number of highly pathogenic viruses. Viral diseases are one of the most important predictors of subsequent bacterial infection. At the same time, we are seeing a worldwide increase in antibiotic use. Despite the fact that in the prevailing percentage terms it has no visible adverse effect, the alteration of the human microbiota can have serious short-term or, worse, long-term consequences for our health. The aim of the review is to trace the relationships between pathogenic viruses, bacteria and the human microbiota. Conclusion: Cocirculation of respiratory pathogens can lead to competitive or cooperative forms of interaction between them. Understanding how our interventions do not cause disruption of the balance of the human microbiota - reduced species diversity, altered metabolic activity, stimulation of selection and sharing of genes responsible for AMR will allow us to adjust strategies to treat infectious diseases. Knowing the interactions between commensal and opportunistic species will help us determine the time when we need to switch from non-pharmacological to pharmacological interventions, preserving the balance of the microbiota and that between it and the macroorganism, as well as reducing the rate of relapses. The right combination of pharmacological, non-pharmacological and dietary interventions in the personalized treatment of patients will allow us to reduce the unnecessary use of antibiotics and better control the risk in the course of diseases.
Keywords: Circulating Pathogens; Microbiota; Probiotics; Prevention; Interactions
