ISSN: 2642-6145
Authors: Lakshmi Chandini M* and Chandrapriyanka B
Cytochrome P450 enzymes (CYPs) play a pivotal role in the metabolism of endogenous compounds and xenobiotics, with their involvement extending to cardiovascular function and disease. This article aims to provide a comprehensive overview of the intricate interplay between CYPs, their modulators, and metabolites in cardiovascular physiology and pathology. Understanding these interactions holds promise for elucidating novel therapeutic targets and interventions in cardiovascular disorders. Cytochrome P450 enzymes, traditionally known for their role in drug metabolism, are increasingly recognized for their involvement in cardiovascular physiology and pathology. This review explores the multifaceted roles of CYPs in cardiovascular homeostasis, including their contribution to vascular tone regulation, inflammation, and oxidative stress. Moreover, it investigates the impact of endogenous and exogenous factors on CYP activity and its implications for cardiovascular health. Dysregulation of CYP-mediated metabolism is implicated in various cardiovascular disorders, offering potential targets for therapeutic intervention. Understanding the complex interplay between CYPs, their modulators, and metabolites sheds light on novel avenues for precision cardiovascular medicine and personalized therapeutic strategies.
Keywords: Cytochrome P450 enzymes; Cardiovascular disease; Vascular tone regulation; Oxidative stress; Drug metabolism; Precision medicine; Therapeutic targets; Pharmacogenomics
